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biotin biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
ATP + biotin-carboxyl-carrier_protein + HCO3- <=> ADP + phosphate + carboxybiotin-carboxyl-carrier_protein 6.3.4.14 biotin carboxylase
6.4.1.1 pyruvate carboxylase


(7R,8S)-diaminononanoate + CO2 + ATP <=> dethiobiotin + phosphate + ADP + H+ 6.3.3.3 dethiobiotin synthase

S-adenosyl-L-methionine + (8S)-8-amino-7-oxononanoate <=> S-adenosyl-4-methylthio-2-oxobutanoate + (7R,8S)-diaminononanoate 2.3.1.47 8-amino-7-oxononanoate synthase
2.6.1.62 adenosylmethionine---8-amino-7-oxononanoate transaminase


carboxyl-carrier_protein + biotin + ATP <=> diphosphate + AMP + biotin-carboxyl-carrier_protein + H+ 6.3.4.15 biotin---[biotin carboxyl-carrier protein] ligase

biotin-carboxyl-carrier_protein <=> biotin-carboxyl-carrier_protein_(dimer) 0.0.0.0

dethiobiotin + sulfur + 2 S-adenosyl-L-methionine <=> biotin + 2 L-methionine + 2 5''-deoxyadenosine 2.8.1.6 biotin synthase

carboxybiotin-carboxyl-carrier_protein + acetyl-CoA <=> biotin-carboxyl-carrier_protein + malonyl-CoA 2.1.3.15 acetyl-CoA carboxytransferase
6.4.1.2 acetyl-CoA carboxylase


pimeloyl-[acyl-carrier_protein] + L-alanine + H+ <=> (8S)-8-amino-7-oxononanoate + CO2 + [acyl-carrier_protein] 2.3.1.47 8-amino-7-oxononanoate synthase

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